(2S)-2-[Diphenyl(methoxy)methyl]tetrahydropyrrole

(2S)-2-[Diphenyl(methoxy)methyl]tetrahydropyrrole - Names and Identifiers

Name	(S)-2-(Methoxydiphenylmethyl)pyrrolidine
Synonyms	-2-(Methoxydiphenylmethyl) (S)-2-(Methoxydiphenylmethyl)pyrrolidine (2S)-2-(METHOXYDIPHENYLMETHYL)PYRROLIDINE (2S)-2-(Methoxydiphenylmethyl)pyrrolidine (2S)-2-[methoxy(diphenyl)methyl]pyrrolidine (2S)-2-[Diphenyl(methoxy)methyl]pyrrolidine Pyrrolidine, 2-(methoxydiphenylmethyl)-, (2S)- (2S)-2-[Diphenyl(methoxy)methyl]tetrahydropyrrole
CAS	118971-03-2
InChI	InChI=1/C18H21NO/c1-20-18(17-13-8-14-19-17,15-9-4-2-5-10-15)16-11-6-3-7-12-16/h2-7,9-12,17,19H,8,13-14H2,1H3/t17-/m0/s1

(2S)-2-[Diphenyl(methoxy)methyl]tetrahydropyrrole - Physico-chemical Properties

Molecular Formula	C18H21NO
Molar Mass	267.37
Density	1.070±0.06 g/cm3(Predicted)
Boling Point	368.7±32.0 °C(Predicted)
Flash Point	157.824°C
Vapor Presure	0mmHg at 25°C
pKa	10.09±0.10(Predicted)
Storage Condition	2-8°C
Refractive Index	1.564

(2S)-2-[Diphenyl(methoxy)methyl]tetrahydropyrrole - Risk and Safety

Hazard Symbols	Xn - Harmful
Risk Codes	22 - Harmful if swallowed
WGK Germany	3

(2S)-2-[Diphenyl(methoxy)methyl]tetrahydropyrrole - Introduction

(S)-2-(methoxydiphenylmethyl) tetrahydropyrrole, also known as (S)-methoxydiphenylmethylpiperidine. The following is a description of the properties, uses, preparation and safety information of the compound:

Nature:
-Appearance: colorless or yellowish liquid
-Molecular formula: C19H23NO
-Molecular weight: 281.39g/mol
-Melting point:-10°C
-Boiling point: 170-172°C
-Density: 1.066 g/mL

Use:
-The compound is commonly used in organic synthesis as a chiral reagent. It is a chiral nitrogen heterocyclic compound commonly used in catalytic or catalytic hydrogenation reactions. It can be used to synthesize other organic compounds, especially in the synthesis of drugs.

Preparation Method:
(S)-2-(methoxydiphenylmethyl) tetrahydropyrrole can be prepared by the following steps:
1.1-Phenyl-2-propanone (1-phenyl-2-propanone) and paraformaldehyde (dimethylaldehyde) are heated to react together to obtain a methyl hydrogen compound.
2. The methyl hydrogen compound is reacted with HCl in acetic anhydride acetic acid solution to generate the product.

Safety Information:
-The compound has low toxicity, but it still needs to be handled carefully. Appropriate laboratory safety practices should be observed when using the compound.
-Avoid skin contact and inhalation of the gas or vapor of the compound, as it may cause irritation or harm to human health.
-Wear appropriate personal protective equipment such as lab gloves and goggles when handling.
-May have adverse effects on the environment, so appropriate measures should be taken when handling and disposing of the compound to avoid environmental pollution.

Last Update：2024-04-09 20:49:11